灌注系統(tǒng)概述
HSE—HA生理學(xué)系統(tǒng)是一系列應(yīng)用廣泛的完備產(chǎn)品，可用于整體動物生理學(xué)、立體或在體器官和組織灌注及組織浴槽研究。這些系統(tǒng)具有廣泛的應(yīng)用，包括傳統(tǒng)的**藥理學(xué)、DMPK、毒理學(xué)、呼吸系統(tǒng)、心臟病學(xué)、分子生物學(xué)和生理學(xué)。每個系統(tǒng)都設(shè)計(jì)了標(biāo)準(zhǔn)的組件，再加一些其他配置以適合特殊研究的需要。。標(biāo)注組件也意味著如果你是需要將現(xiàn)有設(shè)備配齊，或者進(jìn)行系統(tǒng)升級，或者是完整的配套產(chǎn)品，你都只需要購買需要的構(gòu)件。HSE-HA生理學(xué)系統(tǒng)為你提供各種工具，使你的研究走向多產(chǎn)和成功。
我們提供大多數(shù)生理學(xué)檢測設(shè)備，包括放大器、電極、傳感器和電化學(xué)檢測器。參數(shù)包括力、位移、壓力、液體和氣體流、心電圖（單導(dǎo)聯(lián)—12導(dǎo)聯(lián)系統(tǒng)）、MAP（單個或多個部位）、腦電圖、肌電圖、連續(xù)支流灌注傳統(tǒng)的血?dú)鈪?shù)和電解質(zhì)的分析，可以選擇程序化軟件和傳統(tǒng)的刺激器作為放大器、電極和傳感器等產(chǎn)品的補(bǔ)充。
HSE-DAQ系統(tǒng)產(chǎn)品家族（BDAS、ACAD、HAEMODYN、ISOHEART、PULMODYN、PENNOCK）可以記錄你的初始信號，計(jì)算到處的參數(shù)，注釋數(shù)據(jù)，快速簡易的輸入確定的數(shù)據(jù)用于分析。同時還可以選擇用于進(jìn)一步分析的軟件模塊，帶狀記錄紙打印，自動和控制模塊等。產(chǎn)品經(jīng)過預(yù)先設(shè)置，打開包裝即可使用，并專門設(shè)計(jì)符合你的系統(tǒng)配置和數(shù)據(jù)分析要求。
• Investigation of ventilation and perfusion in the isolated rabbit lung
• Optimized in-situ preparation
• Negative-pressure ventilation to mimic closely the in-vivo situation
• Regular induction of hyperinflation of the lung (sigh)
• Perfusion under constant flow condition using buffer solution or blood
• Continuous measurement of lung mechanics (tidal volume, resistance, compliance), and perfusate characteristics (pressure, pCO2, pO2, pH)
• Continuous measurement of lung weight changes (Edema)
Ventilation
When the lung is placed in the artificial thoracic chamber and ventilated at negative pressure, the ventilation head is removed and replaced by the pneumotachometer for the measurement of respiratory flow. The ventilation medium (air or gas mixture) is constantly flowing past the distal end of the pneumotachometer. The breathing frequency can be varied between 30 and 60 breaths/min. In addition, the inspiratory time as a percentage of each breath, can be set between 10 and 90% in 10% steps. The end-inspiratory, end-expiratory, and deep breath (hyperinflationary) negative pressure can be set individually. A deep breath is usually induced every 5 to 20 min.
Constant Flow Perfusion
The constant flow rate of perfusate into the pulmonary artery is determined by a roller pump. The perfusate is stored in a water-jacketed container to maintain constant temperature. Aeration is provided to keep the pH constant. A heat exchanger and a bubble trap are placed next to the pulmonary artery connection for exact adjustment of the perfusate temperature just before the thorax chamber and to prevent air bubbles entering the lung.
Different perfusates can be provided in turn by transferring the suction tube from one reservoir to another; there is no need for prior aeration or temperature control. The use of oxygen-sensitive test substances raises few problems since the contact time with the high oxygen concentration is minimized. It is also possible to vary the gas mixture rapidly during the study.
A Constant Pressure Perfusion System is optionally available. Please call for details.
Lung Mechanics
The pressure inside the thoracic chamber is measured with a MPX pressure transducer. Air flow is determined with the pneumotachometer connected to a Validyne differential pressure transducer DP 45-14. The volume is derived from the air flow by integration. The calculation of pulmonary compliance and resistance needs a computer controlled data acquisition system (HSE-HA Pulmodyn).
• Investigation of ventilation and perfusion in the isolated rabbit lung
• Optimized in-situ preparation
• Negative-pressure ventilation to mimic closely the in-vivo situation
• Regular induction of hyperinflation of the lung (sigh)
• Perfusion under constant flow condition using buffer solution or blood
• Continuous measurement of lung mechanics (tidal volume, resistance, compliance), and perfusate characteristics (pressure, pCO2, pO2, pH)
• Continuous measurement of lung weight changes (Edema)